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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

High-Performance Liquid Chromatography of Biologically Important, Small Epimeric Peptides and their L, D-Amino Acid Content

Author(s): I. Ilisz, Z. Pataj, A. Aranyi and A. Peter

Volume 10, Issue 4, 2010

Page: [287 - 298] Pages: 12

DOI: 10.2174/138955710791330981

Price: $65

Abstract

Since most of the proteinogenic α-amino acids contain a chiral carbon atom, the stereoisomers of both these amino acids and the peptides in which they are to be found may possess differences in biological activity in living systems. The important analytical task of the separation of optical isomers is achieved mainly by chromatographic methods. This special review surveys direct and indirect HPLC separations of biologically important, small epimeric peptides and their L,D-amino acid content.

Keywords: Chirality, enantiomers, peptide epimers, amino acids, high-performance liquid chromatography, chiral derivatizing agents (CDAs), chiral stationary phases (CSPs)


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