High-Performance Liquid Chromatography of Biologically Important, Small Epimeric Peptides and their L, D-Amino Acid Content

Author(s): I. Ilisz, Z. Pataj, A. Aranyi, A. Peter.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 4 , 2010

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Since most of the proteinogenic α-amino acids contain a chiral carbon atom, the stereoisomers of both these amino acids and the peptides in which they are to be found may possess differences in biological activity in living systems. The important analytical task of the separation of optical isomers is achieved mainly by chromatographic methods. This special review surveys direct and indirect HPLC separations of biologically important, small epimeric peptides and their L,D-amino acid content.

Keywords: Chirality, enantiomers, peptide epimers, amino acids, high-performance liquid chromatography, chiral derivatizing agents (CDAs), chiral stationary phases (CSPs)

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Article Details

Year: 2010
Page: [287 - 298]
Pages: 12
DOI: 10.2174/138955710791330981
Price: $58

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