Endocrine, Metabolic & Immune Disorders-Drug Targets

(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Emilio Jirillo  
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico
Bari
Italy

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The Genetics of Obesity and the Metabolic Syndrome

Author(s): Keri L. Monda, Kari E. North, Steven C. Hunt, D.C. Rao, Michael A. Province and Aldi T. Kraja

Affiliation: 137 E. Franklin St, Ste. 306, CB ὲ, Chapel Hill, NC, 27514, USA.

Keywords: Obesity, metabolic syndrome, common complex disease, genetics, GWAS

Abstract:

In this review, we discuss the genetic architecture of obesity and the metabolic syndrome, highlighting recent advances in identifying genetic variants and loci responsible for a portion of the variation in components of the metabolic syndrome, namely, adiposity traits, serum HDL and triglycerides, blood pressure, and glycemic traits. We focus particularly on recent progress from large-scale genome-wide association studies (GWAS), by detailing their successes and how lessons learned can pave the way for future discovery. Results from recent GWAS coalesce with earlier work suggesting numerous interconnections between obesity and the metabolic syndrome, developed through several potentially pleiotropic effects. We detail recent work by way of a case study on the cadherin 13 gene and its relation with adiponectin in the HyperGEN and the Framingham Heart Studies, and its association with obesity and the metabolic syndrome. We provide also a gene network analysis of recent variants related to obesity and metabolic syndrome discovered through genome- wide association studies, and 4 gene networks based on searching the NCBI database.

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Article Details

VOLUME: 10
ISSUE: 2
Page: [86 - 108]
Pages: 23
DOI: 10.2174/187153010791213100