Abstract
Undesired side-effects and toxicities of drugs, especially in the area of new-drug development, are negligibleless, unpredicable and often disastrous once being encountered. Increasing varieties of evidence suggest that the differences of chemical structures of drugs and humans genomic makeup and environmental causes totally decide the occurrences of side-effects and toxicities of drugs instead of chemical structures of a drug alone. The side-effects of central neural systems are relatively easy to be observed and conspicuous and sensitive to judgments with or by fixed grading systems. It could be an important area to systematically study the side-effects of drugs and underlying genetic mechanisms and relationships in between. This review discusses this issue through careful analyzing relevant clinical evidence and published data relating to genetic detection of suffered patients and gives further suggestions to improve.
Keywords: Side-effects of drug, human genome, genomic research, drug development, drug safety, medicinal chemistry
Central Nervous System Agents in Medicinal Chemistry
Title: Undesired Neural Side-Effects of a Drug, a Chemical and Genetic Interrelated Problem
Volume: 10 Issue: 2
Author(s): Da Yong Lu, Ting Ren Lu and Peng Peng Zhu
Affiliation:
Keywords: Side-effects of drug, human genome, genomic research, drug development, drug safety, medicinal chemistry
Abstract: Undesired side-effects and toxicities of drugs, especially in the area of new-drug development, are negligibleless, unpredicable and often disastrous once being encountered. Increasing varieties of evidence suggest that the differences of chemical structures of drugs and humans genomic makeup and environmental causes totally decide the occurrences of side-effects and toxicities of drugs instead of chemical structures of a drug alone. The side-effects of central neural systems are relatively easy to be observed and conspicuous and sensitive to judgments with or by fixed grading systems. It could be an important area to systematically study the side-effects of drugs and underlying genetic mechanisms and relationships in between. This review discusses this issue through careful analyzing relevant clinical evidence and published data relating to genetic detection of suffered patients and gives further suggestions to improve.
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Cite this article as:
Yong Lu Da, Ren Lu Ting and Peng Zhu Peng, Undesired Neural Side-Effects of a Drug, a Chemical and Genetic Interrelated Problem, Central Nervous System Agents in Medicinal Chemistry 2010; 10 (2) . https://dx.doi.org/10.2174/187152410791196396
DOI https://dx.doi.org/10.2174/187152410791196396 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
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