Esters of Dehydroepiandrosterone (DHEA) as Probes for the Active Site of Type 3 17β-Hydroxysteroid Dehydrogenase (17β-HSD3)
Moniola S. Olusanjo,
Caroline P. Owen,
We report the use of steroid-based compounds as probes for the active site of 17β-hydroxysteroid dehydrogenase, in particular, type 3 (17β-HSD3). Results suggest that the compounds were good inhibitors of 17β-HSD3 – a number were extremely potent with respect to the standard compounds used.
Keywords: 17β-hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme, Steroid-based compound
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