Synthesis and Antimycobacterial Activity of 2-aryl-3-(arylmethyl)-1,3-thiazolidin-4-ones

Author(s): Claudia R.B. Gomes, Marcele Moreth, Victor Facchinetti, Marcus V.N. de Souza, Walcimar T. Vellasco Junior, Maria Cristina da Silva Lourenco, Wilson Cunico.

Journal Name: Letters in Drug Design & Discovery

Volume 7 , Issue 5 , 2010

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Abstract:

Fifteen new heterocyclic thiazolidinones have been synthesized from one-pot reactions of piperonylamine, arenealdehydes and mercaptoacetic acid. These compounds plus ten 2-aryl-3-(benzyl)-1,3-thiazolidin-4-ones which had been previously synthesized, were evaluated as antibacterial agents against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility test and their activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. Six of the series exhibited modest activity when compared to the first line drugs such as isoniazid (INH) and rifampicin (RIP). Therefore this class of compounds could be a good starting point to develop new lead compounds in the treatment of multi-drug resistant tuberculosis.

Keywords: Tuberculosis, Thiazolidinones, Drugs

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Article Details

VOLUME: 7
ISSUE: 5
Year: 2010
Page: [353 - 358]
Pages: 6
DOI: 10.2174/157018010791163451
Price: $58

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