Abstract
The objective was to characterize the non-oscillatory independent components (ICs) of the auditory event-related potential (ERP) waveform of an oddball task for normal and newly diagnosed Alzheimers disease (AD) subjects, and to seek biomarkers for AD. Single trial ERP waveforms were analysed using independent components analysis (ICA) and k-means clustering. Two stages of clustering depended upon the magnitudes and latencies, and the scalp topographies of the non-oscillatory back-projected ICs (BICs) at electrode Cz. The electrical current dipole sources of the BICs were located using Low Resolution Electromagnetic Tomography (LORETA). Generally 3-10 BICs, of different latencies and polarities, occurred in each trial. Each peak was associated with positive and negative BICs. The trial-to-trial variations in their relative numbers and magnitudes may explain the variations in the averaged ERP reported, and the delay in the averaged P300 for AD patients. The BIC latencies, topographies and electrical current density maximum locations varied from trial-to-trial. Voltage foci in the BIC topographies identify the BIC source locations. Since statistical differences were found between the BICs in healthy and AD subjects, the method might provide reliable biomarkers for AD, if these findings are reproduced in a larger study, independently of other factors influencing the comparison of the two populations. The method can extract artefact- and EEG-free single trial ERP waveforms, offers improved ERP averages by selecting the trials on the basis of their BICs, and is applicable to other evoked potentials, conditions and diseases.
Keywords: Auditory event-related potential (AERP), Alzheimer's disease (AD), Independent component analysis (ICA), Blind source separation (BSS)
Current Alzheimer Research
Title: Waveform Analysis of Non-Oscillatory Independent Components in Single-Trial Auditory Event-Related Activity in Healthy Subjects and Alzheimers Disease Patients
Volume: 7 Issue: 4
Author(s): B.W. Jervis, S. Belal, T. Cassar, M. Besleaga, C. Bigan, K. Michalopoulos, M. Zervakis, K. Camilleri and S. Fabri
Affiliation:
Keywords: Auditory event-related potential (AERP), Alzheimer's disease (AD), Independent component analysis (ICA), Blind source separation (BSS)
Abstract: The objective was to characterize the non-oscillatory independent components (ICs) of the auditory event-related potential (ERP) waveform of an oddball task for normal and newly diagnosed Alzheimers disease (AD) subjects, and to seek biomarkers for AD. Single trial ERP waveforms were analysed using independent components analysis (ICA) and k-means clustering. Two stages of clustering depended upon the magnitudes and latencies, and the scalp topographies of the non-oscillatory back-projected ICs (BICs) at electrode Cz. The electrical current dipole sources of the BICs were located using Low Resolution Electromagnetic Tomography (LORETA). Generally 3-10 BICs, of different latencies and polarities, occurred in each trial. Each peak was associated with positive and negative BICs. The trial-to-trial variations in their relative numbers and magnitudes may explain the variations in the averaged ERP reported, and the delay in the averaged P300 for AD patients. The BIC latencies, topographies and electrical current density maximum locations varied from trial-to-trial. Voltage foci in the BIC topographies identify the BIC source locations. Since statistical differences were found between the BICs in healthy and AD subjects, the method might provide reliable biomarkers for AD, if these findings are reproduced in a larger study, independently of other factors influencing the comparison of the two populations. The method can extract artefact- and EEG-free single trial ERP waveforms, offers improved ERP averages by selecting the trials on the basis of their BICs, and is applicable to other evoked potentials, conditions and diseases.
Export Options
About this article
Cite this article as:
Jervis B.W., Belal S., Cassar T., Besleaga M., Bigan C., Michalopoulos K., Zervakis M., Camilleri K. and Fabri S., Waveform Analysis of Non-Oscillatory Independent Components in Single-Trial Auditory Event-Related Activity in Healthy Subjects and Alzheimers Disease Patients, Current Alzheimer Research 2010; 7 (4) . https://dx.doi.org/10.2174/156720510791162412
DOI https://dx.doi.org/10.2174/156720510791162412 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Multi-Pharmacophore Modeling of Caspase-3 Inhibitors using Crystal, Dock and Flexible Conformation Schemes
Combinatorial Chemistry & High Throughput Screening Role of the Hypoxic Microenvironment in the Antitumor Activity of Tyrosine Kinase Inhibitors
Current Medicinal Chemistry Human T-Cell Lymphotropic Virus in Patients Infected with HIV-1: Molecular Epidemiology and Risk Factors for Transmission in Piaui, Northeastern Brazil
Current HIV Research Anticancer Drug Discovery from the Marine Environment
Recent Patents on Anti-Cancer Drug Discovery Point of Care Cardiac Ultrasound Applications in the Emergency Department and Intensive Care Unit - A Review
Current Cardiology Reviews Industrial Applications of C-C Coupling Reactions
Current Organic Synthesis The Cardiovascular Nutrapharmacology of Resveratrol: Pharmacokinetics, Molecular Mechanisms and Therapeutic Potential
Current Medicinal Chemistry Use of STAT1 Inhibitors in the Treatment of Brain I/R Injury and Neurodegenerative Diseases
Central Nervous System Agents in Medicinal Chemistry Towards Isozyme-Selective HDAC Inhibitors For Interrogating Disease
Current Topics in Medicinal Chemistry <i>Cannabis Sativa</i> L. Flower and Bud Extracts Inhibited <i>In vitro</i> Cholinesterases and β-Secretase Enzymes Activities: Possible Mechanisms of Cannabis Use in Alzheimer Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets Coenzyme Q10 and Neurological Diseases: An Update
Letters in Drug Design & Discovery One-Pot Synthesis of (3-Phenylisoxazol-5-yl)methanol Derivatives Under Ultrasound
Letters in Organic Chemistry Pharmacological Approaches of Alzheimer's Disease: An Update
Current Drug Therapy Significance of Green Synthetic Chemistry from a Pharmaceutical Perspective
Current Pharmaceutical Design Phenomics of Vascular Disease: The Systematic Approach to the Combination Therapy
Current Vascular Pharmacology Function and Regulation of Tumor Necrosis Factor Receptor Type 2
Current Medicinal Chemistry Physiological Roles of Neuronal Nicotinic Receptors Subtypes: New Insights on the Nicotinic Modulation of Neurotransmitter Release, Synaptic Transmission and Plasticity
Current Topics in Medicinal Chemistry Metals, Toxicity and Oxidative Stress
Current Medicinal Chemistry A Review of Voltammetric Methods for Determination of Dopamine Agonists
Current Analytical Chemistry Correlation between Systemic Lupus Erythematosus Activity and Plasma Levels of Monomeric Prolactin and Macroprolactin
Endocrine, Metabolic & Immune Disorders - Drug Targets