Imaging as a Strategy for Premortem Diagnosis and Staging of Tauopathies

Author(s): S. Kim, J.R. Jensen, K. Cisek, K.E. Funk, S. Naphade, K. Schafer, J. Kuret.

Journal Name: Current Alzheimer Research

Volume 7 , Issue 3 , 2010

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Abstract:

Alzheimers disease is diagnosed by postmortem detection of pathological lesions that accumulate in specific brain regions. Although the presence of both β-amyloid plaques and tau-bearing neurofibrillary lesions defines Alzheimers disease, the distribution of neurofibrillary lesions alone correlates strongly with neurodegeneration and cognitive decline. A whole-brain imaging test capable of detecting these lesions in premortem cases could have great potential for staging and differentially diagnosing Alzheimers disease. Here we discuss the challenges in developing a whole-brain imaging approach for detection of this intracellular target.

Keywords: Alzheimer's disease, frontotemporal lobar degeneration, tau, neurofibrillary tangle, paired helical filaments

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2010
Page: [230 - 234]
Pages: 5
DOI: 10.2174/156720510791050894
Price: $58

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