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Current Alzheimer Research
ISSN (Print): 1567-2050
ISSN (Online): 1875-5828
VOLUME: 7
ISSUE: 3
DOI: 10.2174/156720510791050957      Price:  $58









Fragile X Syndrome and Alzheimers Disease: Another Story About APP and β -Amyloid

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Author(s): J.S. Malter, B.C. Ray, P.R. Westmark and C.J. Westmark
Pages 200-206 (7)
Abstract:
As the mechanisms underlying neuronal development and degeneration become clarified, a number of common effectors and signaling pathways are becoming apparent. Here we describe the identification of Aβ, long considered a pathologic mediator of Alzheimers Disease and Down Syndrome, as similarly over-expressed in the neurodevelopmental disease, Fragile X Syndrome. We also show that mGluR5 inhibitors, currently employed for the treatment of Fragile X, reduce Aβ production in rodent models of Fragile X and AD as well as reduce disease phenotypes including seizures. Thus seemingly disparate neurologic diseases may share a common pathologic instigator and be treatable with a common, currently available class of therapeutics.
Keywords:
Metabotropic glutamate receptors (mGluR), Fragile X Syndrome (FXS), amyloid precursor protein (APP), beta-amyloid
Affiliation:
R509T, Waisman Center, 1500 Highland Ave, Madison, WI 53705, USA.