Artosimmin- A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus

Author(s): Gwendoline C.L. Ee, Siow H. Teo, Mawardi Rahmani, Chan K. Lim, Yang M. Lim, Choon F.J. Bong.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 3 , 2010

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Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH).

Keywords: Artocarpus odoratissimus, moraceae, pyranoflavone, triterpenoid, cytotoxicity, antioxidant

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Article Details

Year: 2010
Page: [240 - 244]
Pages: 5
DOI: 10.2174/157017810791112379
Price: $65

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