A Procedure for Facile Synthesis of Nucleosides Using N, O-Bistrimethylsilylacetamide in the Presence of Natural Phosphate Coated with Potassium Iodide

Author(s): Laila Baddi, Michael Smietana, Said Sebti, Jean-Jacques Vasseur, Hassan B. Lazrek.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 3 , 2010

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Abstract:

Several α-D/L-arabino and β-D/L- xylonucleosides were synthesized in good yields under mild conditions by N-glycosylation of 1-O-acetyl D/L- arabino, and xylofuranose, with silylated nucleobases (uracil, thymine and 6- azauracil) in acetonitrile using natural phosphate (NP) coated with potassium iodide in BSA as catalyst.

Keywords: N-Glycosylation, D/L nucleosides, natural phosphate, catalyst

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2010
Page: [196 - 199]
Pages: 4
DOI: 10.2174/157017810791112441
Price: $65

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