Synthesis Optimization of Hydroxymethylnitrofurazone, an Antichagasic Candidate, Using 32 Factorial Design

Author(s): Gustavo H.G. Trossini, Jeanine Giarolla, Leandro de Rezende, Antonia T. do Amaral, Marcio H. Zaim, Roy E. Bruns, Elizabeth I. Ferreira.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 3 , 2010

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Abstract:

Hydroxymethylnitrofurazone presents in vitro activity against Trypanosoma cruzi. The optimization of the synthesis of this compound was performed through a 32 factorial statistical design. Quadratic model produced the best response surface predicting a maximum yield (82%) close to the center design point with a seven hours reaction and a 1:1.5 (NF:K2CO3) ratio.

Keywords: Factorial design, synthesis optimization, hydroxymethylnitrofurazone (NFOH), antichagasic candidate, response surface methodology

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2010
Page: [191 - 195]
Pages: 5
DOI: 10.2174/157017810791112513
Price: $65

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