Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents

Author(s): Guizhi Xiao, Hao Fang, Chengguo Xing, Wenfang Xu.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 14 , 2009

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Abstract:

Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.

Keywords: Apoptosis, Bcl-2, structure, function, inhibitors, anti-tumor

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Article Details

VOLUME: 9
ISSUE: 14
Year: 2009
Page: [1596 - 1604]
Pages: 9
DOI: 10.2174/138955709791012238
Price: $58

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