Gastrin: An Acid-Releasing, Proliferative and Immunomodulatory Peptide?

Author(s): Sara Calatayud, Angeles Alvarez, Victor M. Victor.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 1 , 2010

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Abstract:

Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.

Keywords: Gastrin, inflammation, immunomodulation, CCK-2 receptors, CCK-2 receptor antagonists

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Article Details

VOLUME: 10
ISSUE: 1
Year: 2010
Page: [8 - 19]
Pages: 12
DOI: 10.2174/138955710791112532

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