Polyketides from Marine Dinoflagellates of the Genus Prorocentrum, Biosynthetic Origin and Bioactivity of Their Okadaic Acid Analogues

Author(s): Weimin Hu, Jing Xu, Jari Sinkkonen, Jun Wu.

Journal Name:Mini-Reviews in Medicinal Chemistry

Volume 10 , Issue 1 , 2010

Abstract:

Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.

Keywords: Dinoflagellate, Prorocentrum, polyketide, okadaic acid, biosynthetic origin, inhibition to PP1 and PP2A, pharmacophore

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Article Details

VOLUME: 10
ISSUE: 1
Year: 2010
Page: [51 - 61]
Pages: 11
DOI: 10.2174/138955710791112541