Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin

Author(s): A. Siano, G. Tonarelli, M. S. Imaz, J. C. Perin, N. Ruggeri, M. Lopez, M. N. Santi, E. Zerbini.

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 4 , 2010

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Abstract:

Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most active peptide was Gr-1C, containing a disulphide bridge, with Minimal Inhibitory Concentration value of 10.1 μM. In concentrations of up to 50 μM, Gr-1 and Gr2 didnt exceed 30% of hemolysis.

Keywords: Antimicrobial peptides, Mycobacterium tuberculosis, granulysin, synthetic peptides

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Article Details

VOLUME: 17
ISSUE: 4
Year: 2010
Page: [517 - 521]
Pages: 5
DOI: 10.2174/092986610790963555
Price: $58

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