Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives

Author(s): Marcelle de L. Ferreira, Andre L.P. Candea, Maria das Gracas M. de O. Henriques, Carlos R. Kaiser, Camilo H. da S. Lima, Marcus V.N. de Souza.

Abstract:

A series of seventeen disubstituted N-acylhydrazone pyrazinecarbohydrazide (4-20) have been synthesized and evaluated for their cell viabilities, were compared to another monosubstituted derivatives previously synthesized by us. This study indicated that the position and nature of the substituents in the aromatic ring influence the cytotoxicity of this series.

Keywords: Pyrazine, N-acylhydrazones, Tuberculosis, Drugs

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2010
Page: [275 - 280]
Pages: 6
DOI: 10.2174/157018010790945814
Price: $58