Current Nutrition & Food Science

Undurti N. Das  
UND Life Sciences
Shaker Heights
OH 44120
USA

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Naturally Occurring Regulators of Histone Acetylation/Deacetylation

Author(s): Florence Folmer, Barbora Orlikova, Michael Schnekenburger, Mario Dicato, Marc Diederich.

Abstract:

Acetylation and deacetylation of lysine residues on histones, which are catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), are epigenetic modifications that play a very important role in the regulation of gene transcription. Perturbation of the balance between histone acetylation and deacetylation leads to a myriad of diseases, including cancer, AIDS, malaria, neurodegenerative diseases, and diabetes. HATs and HDACs have recently been recognized as key targets for chemoprevention and drug discovery, and numerous natural and synthetic compounds have been screened in order to identify promising regulators of subtle balance between histone acetylation and deacetylation. Here, we present dietary compounds and other natural products that have emerged as potent HAT or HDAC activity modulators, and we discuss their current and future applications as chemopreventive or therapeutic agents.

Keywords: Acetylome, histone acetyl transferase, histone deacetylase, cancer, HDAC/HAT inhibitors, natural products

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2010
Page: [78 - 99]
Pages: 22
DOI: 10.2174/157340110790909581