Current Vascular Pharmacology

Dimitri P. Mikhailidis  
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG


Animal Models for Studying Neointima Formation

Author(s): Jamie Y. Jeremy and Anita C. Thomas

Affiliation: Department of Cardiac Surgery,Bristol Heart Institute, University of Bristol, Bristol, UK.


Neointima (NI) formation following arterial bypass graft surgery or balloon angioplasty is considered central to subsequent failure after these procedures. The NI promotes accelerated atherogenesis, re-occlusion and thrombosis resulting in a failure rate as high as 50% within 1-10 years. Furthermore, despite the relative success of statins and drug eluting stents, drugs that reduce the failure rate have as yet not been implemented. In turn, animal models are a crucial means of testing potential interventions, in particular, drugs. The objective of this review therefore is to provide a survey of all the possible models that can be used to explore the effects of drugs on NI formation. The review will focus on the most commonly used of species, namely the rat, rabbit, mouse, pig and dog.

Keywords: Neointima, bypass graft, balloon angioplasty, stent, restenosis, atherosclerosis, animal model

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Article Details

Page: [198 - 219]
Pages: 22
DOI: 10.2174/157016110790887027
Price: $58