Current Respiratory Medicine Reviews

Joseph Varon  
The University of Texas Health Science Center
Houston, TX


Relationship Between Virulence Factors and Outcome of Ventilator-Associated Pneumonia Related to Pseudomonas aeruginosa

Author(s): Lorenzo Berra, Ulrich Schmidt, Jeanine Wiener-Kronish.


Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative, aerobic, rod-shaped and polar-flagella bacterium with unipolar motility, and an opportunistic pathogen responsible for ventilator-acquired pneumonia (VAP). VAP due to P. aeruginosa is usually multidrug-resistant and associated with severe infection and increased mortality. The large genome and the high level of gene regulation may explain part of the significant virulence and of the prominent adaptability to different environments of this pathogen. In this review, we discussed the potential relationship between some of the virulent factors of P. aeruginosa and outcome of patient with VAP.

Keywords: Ventilator-associated pneumonia, Pseudomonas aeruginosa, Pseudomonas aeruginosa bacterial cell surface virulence factors, Pseudomonas aeruginosa secreted virulence factors, Pseudomonas aeruginosa type III secretion system, Pseudomonas aeruginosa quorum-sensing

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Article Details

Year: 2010
Page: [19 - 25]
Pages: 7
DOI: 10.2174/157339810790820458