The Role of Continuous Positive Airway Pressure in the Treatment of Hypertension in Patients with Obstructive Sleep Apnea-Hypoapnea Syndrome: A Review of Randomized Trials
Mohan Rao, Geet Rajda, Sarada Uppuluri, G. Ronald Beck, Lynn Liu and John D. Bisognano
Affiliation: University of Rochester Medical Center, 601 Elmwood Avenue, Box 679-7, Rochester, New York 14642, USA.
Keywords: Continuous positive airway pressure, hypertension, nasal continuous positive airway pressure, obstructive sleep apnea, sleep apnea, sleep apnea-hypoapnea
Obstructive sleep apnea-hypoapnea syndrome (OSA) is a disorder that results in repetitive occlusion of the airway and hypoxemia during sleep. Epidemiologic studies have associated this disorder with increased cardiovascular morbidity and mortality. Systemic hypertension is prevalent among patients with OSA and it has been recognized as a common identifiable cause of hypertension. Nasal continuous positive airway pressure (nCPAP) ventilation is an effective therapy for OSA and may also reduce blood pressure. The use of nCPAP ventilation to treat hypertension in patients with OSA has been studied extensively. However, whether it is effective in treating hypertension in this population remains unclear. This review evaluates the recent literature that investigates the effects of nCPAP ventilation on hypertension in patients with OSA.
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