Enzymatic Synthesis of Dipeptides in Ionic Liquids

Author(s): Sanjay V. Malhotra, Chengdong Zhang, Hao Wang.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 2 , 2010

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Abstract:

Immobilized protease-catalyzed synthesis of peptides from natural amino acids has been achieved in ionic liquids (ILs). Three ionic liquids BMIM.PF6, BMIM.BF4 and EtPy.BF4 have been tested; an effective yet simple and practical method has been devised. The product yields are comparable with those seen in molecular solvents. A max yield of 49 % for Boc-Leu-TrpOEt has been obtained. This study shows that the advantages seen in organic solvents can also be achieved in ILs, and use of such medium could provide a viable alternative to organic and aqueous media for biocatalysis.

Keywords: Enzymatic synthesis, protease, dipeptides, ionic liquid

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2010
Page: [168 - 171]
Pages: 4
DOI: 10.2174/157017810790796318
Price: $58

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