Synthesis of Novel Succinic Acid Derivatives as Potential Matrix Metalloproteinases Inhibitors and Anticancer Medicine

Title: Synthesis of Novel Succinic Acid Derivatives as Potential Matrix Metalloproteinases Inhibitors and Anticancer Medicine

Volume: 7 Issue: 2

Author(s): Huiming Huang, Dan Chen, Shaohua Li and Chengmei Liu

Affiliation:

Keywords: Tartaric acid, malic acid, thiadiazole, acylation, nucleophilic substitution, matrix metalloproteinase inhibitors

Abstract: In this paper we have designed different methods, according to the differences in nucleophilicity of amino, to conjugate tartaric acid or malic acid with two kinds of useful intermediates respectively via amide bond, envisaging they are promising matrix metalloproteinase inhibitors or anticancer medicine.

Cite this article as:

Huang Huiming, Chen Dan, Li Shaohua and Liu Chengmei, Synthesis of Novel Succinic Acid Derivatives as Potential Matrix Metalloproteinases Inhibitors and Anticancer Medicine, Letters in Organic Chemistry 2010; 7 (2) . https://dx.doi.org/10.2174/157017810790796336