Synthesis of Novel Succinic Acid Derivatives as Potential Matrix Metalloproteinases Inhibitors and Anticancer Medicine

Author(s): Huiming Huang, Dan Chen, Shaohua Li, Chengmei Liu.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 2 , 2010

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Abstract:

In this paper we have designed different methods, according to the differences in nucleophilicity of amino, to conjugate tartaric acid or malic acid with two kinds of useful intermediates respectively via amide bond, envisaging they are promising matrix metalloproteinase inhibitors or anticancer medicine.

Keywords: Tartaric acid, malic acid, thiadiazole, acylation, nucleophilic substitution, matrix metalloproteinase inhibitors

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2010
Page: [155 - 158]
Pages: 4
DOI: 10.2174/157017810790796336
Price: $58

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