Regioselective Amination of 3-Bromoindolylmaleimide with Amines

Author(s): Di-Fa Jiang, Yan-Wu Yang, Zhi-Yu Shao, Sheng-Yin Zhao.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 2 , 2010

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3-Bromoindolylmaleimide and bisindolylmaleimide were synthesized from succinimide in three steps sequnence consisting of bromination, N-methylation and indole addition in the presence of magnesium and bromoethane. They were subjeced to the regioselective amination with substituted amines to provide 3-aminoindolylmaleimides, 3- amino-N-alkylated indolylmaleimides and N-alkylated bisindolylmaleimides in good yields. The resulting indolylmaleimides represent a new class of potentially bioactive compounds.

Keywords: 3-Bromoindolylmaleimide, bisindolylmaleimide, regioselective amination, reaction mechanism

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Article Details

Year: 2010
Page: [144 - 148]
Pages: 5
DOI: 10.2174/157017810790796200
Price: $58

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