Synthesis, CI-MS Analyses and Preliminary Biological Evaluation of a Novel Library of Hydrophobic Persulfide-Spacers α-Alkyl Glycosides

Author(s): Hammed H. A.M. Hassan.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 2 , 2010

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Abstract:

We report the synthesis of novel polyether-based polyols derived from simple glycosides that bear sulfur spacers in the attempt to potentially provide new antibiotics. The CI-MS demonstrated the stepwise and successive fission of the sulfide-spacer groups; however, it does not distinguish between the alditols having different arrangement of O- (CH2)3-S(CH2)2OH groups. The investigated compounds exhibited antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and antifungal activities against Candida albicans at a concentration of 1 mg / ml in DMF.

Keywords: Carbohydrates, perallyl glycosides, AIBN, sulfide spacer, antimicrobial

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2010
Page: [127 - 135]
Pages: 9
DOI: 10.2174/157017810790796372
Price: $58