Benzoxazine and Benzodioxine as Indole Isosteres in Indolocarbazoles Series: Synthesis and Biological Evaluation

Author(s): Nathalie Ayerbe, Sylvain Routier, Isabelle Gillaizeau, Sebastien Tardy, Gerard Coudert.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 2 , 2010

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Abstract:

New series of structure based on original benzodioxine and benzoxazine heterocycles were prepared leading to potential anticancer lead compounds. In this paper, we described a convenient approach via a Diels-Alder cycloaddition in order to efficiently provide three new indole isosteres in indolocarbazoles series. Their first cytotoxic evaluation was also reported.

Keywords: Benzodioxine, benzoxazine, indolocarbazole, cytotoxicity

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2010
Page: [121 - 126]
Pages: 6
DOI: 10.2174/157017810790796291
Price: $58

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