A Convenient Methodology for Nitro-Michael Addition of Carbonyl Compounds Catalyzed by L-Proline Using Microwave Heating

Author(s): Alessio Russo, Nicholas E. Leadbeater, Alessandra Lattanzi.

Journal Name: Letters in Organic Chemistry

Volume 7 , Issue 2 , 2010

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Abstract:

Michael addition of aldehydes and ketones to trans-β-nitrostyrene catalyzed by L-proline was investigated using microwave heating for rapid optimization of reaction conditions. The products could be obtained, easily in very short reaction times, high yields and comparable diastereo- and enantioselectivity with respect to the original procedures, under simple and more environmentally benign conditions such as the use of ethanol as the solvent and only a slight excess of the carbonyl compound.

Keywords: Michael addition, organocatalysis, L-proline, carbonyl compounds, microwave irradiation, conventional heating

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2010
Page: [98 - 102]
Pages: 5
DOI: 10.2174/157017810790796219
Price: $58

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