A Convenient Methodology for Nitro-Michael Addition of Carbonyl Compounds Catalyzed by L-Proline Using Microwave Heating

Title: A Convenient Methodology for Nitro-Michael Addition of Carbonyl Compounds Catalyzed by L-Proline Using Microwave Heating

Volume: 7 Issue: 2

Author(s): Alessio Russo, Nicholas E. Leadbeater and Alessandra Lattanzi

Affiliation:

Keywords: Michael addition, organocatalysis, L-proline, carbonyl compounds, microwave irradiation, conventional heating

Abstract: Michael addition of aldehydes and ketones to trans-β-nitrostyrene catalyzed by L-proline was investigated using microwave heating for rapid optimization of reaction conditions. The products could be obtained, easily in very short reaction times, high yields and comparable diastereo- and enantioselectivity with respect to the original procedures, under simple and more environmentally benign conditions such as the use of ethanol as the solvent and only a slight excess of the carbonyl compound.

Cite this article as:

Russo Alessio, Leadbeater E. Nicholas and Lattanzi Alessandra, A Convenient Methodology for Nitro-Michael Addition of Carbonyl Compounds Catalyzed by L-Proline Using Microwave Heating, Letters in Organic Chemistry 2010; 7 (2) . https://dx.doi.org/10.2174/157017810790796219