Central Nervous System Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Central Nervous System Agents)

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A Dual Activity of ROS and Oxidative Stress on Adult Neurogenesis and Alzheimers Disease

Author(s): Philippe Taupin.

Abstract:

Oxidative stress is a deleterious condition leading to cellular death. It plays a key role in the development and pathology of neurodegenerative diseases, like Alzheimers disease (AD). AD is the most common form of dementia among elderly. Genetic mutations and genetic, acquired and environmental risk factors, particularly neuroinflammation and oxidative stress, are the main causes of AD. Neurogenesis occurs in the adult brain of mammals, particularly in the hippocampus, and is enhanced in the brain of patients with AD. Enhanced neurogenesis in AD may represent an attempt by the central nervous system to compensate for the neuronal loss and repair itself. Reactive oxygen species (ROS) promote cell death and the nondisjunction of chromosomes, leading to aneuploidy. The activity of ROS on newly generated neuronal cells in the adult brain may contribute to the pathogenesis of AD. Antioxidant may be used to reduce the deleterious activity of ROS, particularly on newly generated neuronal cells of the adult brain, potentially delaying the development of AD and promoting the regenerative capacity of the adult brain.

Keywords: Aneuploidy, apoptosis, cell cycle, neurodegeneration, neurological diseases, reactive oxygen species, regeneration, stem cells

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Article Details

VOLUME: 10
ISSUE: 1
Year: 2010
Page: [16 - 21]
Pages: 6
DOI: 10.2174/187152410790780172