High Mobility Group Box 1 Protein as a Potential Drug Target for Infection- and Injury-Elicited Inflammation

Author(s): Shu Zhu, Wei Li, Mary F. Ward, Andrew E. Sama, Haichao Wang.

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)

Volume 9 , Issue 1 , 2010

Abstract:

In response to infection or injury, a ubiquitous nucleosomal protein, HMGB1 is secreted actively by innate immune cells, and/or released passively by injured/damaged cells. Subsequently, extracellular HMGB1 alerts, recruits, and activates various innate immune cells to sustain a rigorous inflammatory response. A growing number of HMGB1 inhibitors ranging from neutralizing antibodies, endogenous hormones, to medicinal herb-derived small molecules (such as nicotine, glycyrrhizin, tanshinones, and EGCG) are proven protective against lethal infection and ischemic injury. Here we review emerging evidence that support extracellular HMGB1 as a proinflammatory alarmin(g) danger signal, and discuss a wide array of HMGB1 inhibitors as potential therapeutic agents for sepsis and ischemic injury.

Keywords: Innate immune cells, phagocytes, inflammation, cytokines, sepsis, antibodies, HMGB1, tanshinones

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2010
Page: [60 - 72]
Pages: 13
DOI: 10.2174/187152810791292872

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