Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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DPPH Scavenging Assay of Novel 1,3-disubstituted-1H-pyrazol-5-ols and their in silico Studies on Some Proteins Involved in Alzheimers Disease Signaling Cascade

Author(s): Balladka Kunhanna Sarojini, Marakkur Vidyagayatri, Chenna Govindaraju Darshanraj, Basavapattana Rudresh Bharath, Hanumanthappa Manjunatha.

Abstract:

A series of new 1,3-disubstituted-1H-pyrazol-5-ols (3) which are the analogues of known radical scavenger ‘edaravone’ are synthesized, characterized and evaluated for DPPH scavenging capacity. The docking studies are carried out for these compounds in the enol form and also in the respective keto form against the proteins and peptides involved in Alzhemier disease signal cascade. Some of them showed good radical scavenging capacity and molecular binding.

Keywords: AD, Pyrazole derivative, DPPH assay, Molecular docking studies, GSK-3β, β-secretase

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2010
Page: [214 - 224]
Pages: 11
DOI: 10.2174/157018010790596588
Price: $58