DPPH Scavenging Assay of Novel 1,3-disubstituted-1H-pyrazol-5-ols and their in silico Studies on Some Proteins Involved in Alzheimers Disease Signaling Cascade

Title: DPPH Scavenging Assay of Novel 1,3-disubstituted-1H-pyrazol-5-ols and their in silico Studies on Some Proteins Involved in Alzheimers Disease Signaling Cascade

Volume: 7 Issue: 3

Author(s): Balladka Kunhanna Sarojini, Marakkur Vidyagayatri, Chenna Govindaraju Darshanraj, Basavapattana Rudresh Bharath and Hanumanthappa Manjunatha

Affiliation:

Keywords: AD, Pyrazole derivative, DPPH assay, Molecular docking studies, GSK-3β, β-secretase

Abstract: A series of new 1,3-disubstituted-1H-pyrazol-5-ols (3) which are the analogues of known radical scavenger ‘edaravone’ are synthesized, characterized and evaluated for DPPH scavenging capacity. The docking studies are carried out for these compounds in the enol form and also in the respective keto form against the proteins and peptides involved in Alzhemier disease signal cascade. Some of them showed good radical scavenging capacity and molecular binding.

Cite this article as:

Sarojini Kunhanna Balladka, Vidyagayatri Marakkur, Darshanraj Govindaraju Chenna, Bharath Rudresh Basavapattana and Manjunatha Hanumanthappa, DPPH Scavenging Assay of Novel 1,3-disubstituted-1H-pyrazol-5-ols and their in silico Studies on Some Proteins Involved in Alzheimers Disease Signaling Cascade, Letters in Drug Design & Discovery 2010; 7 (3) . https://dx.doi.org/10.2174/157018010790596588