Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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5-Sulfonamide Benzimidazoles: A Class of Cannabinoid Receptors Agonists with Potent In Vivo Antinociception Activity

Author(s): Daniel Page, Zhongyong Wei, Ziping Liu, Maxime Tremblay, Helene Desfosses, Claire Milburn, Sanjay Srivastava, Hua Yang, William Brown, Christopher Walpole, Mirek Tomaszewski, Stephane St-Onge, Etienne Lessard, Kemal Payza, Rosemarie Panetta, Xiao Hong Yu, Thierry Hong Groblewski.

Abstract:

The synthesis and biological evaluation of a novel class of cannabinoid receptor agonists based on a 5- sulfonamide benzimidazole scaffold are reported. They showed a high binding affinity to both receptors with great in vivo potency. When given orally to rats, they produced a robust analgesia in different models of inflammatory and neuropathic pain.

Keywords: Benzimidazoles, Cannabinoid agonists, Antinociception

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2010
Page: [208 - 213]
Pages: 6
DOI: 10.2174/157018010790596669
Price: $58