Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Cationic Micellar-Catalyzed Hydrolysis of Pesticide Fenitrothion Using α-Nucleophiles

Author(s): Shuchi Tiwari, Kallol K. Ghosh, Jan Marek, Kamil Kuca.

Abstract:

Comparative nucleophilicity of various α-nucleophiles like butane 2, 3-dione monoxime (BDMO), pralidoxime (2-PAM) and benzohydroxamic acid (BHA) towards hydrolysis of pesticide fenitrothion has been measured in the presence of various cationic surfactants at 27°C. It is shown that butane 2, 3-dione monoxime exhibits more reactivity for the degradation of fenitrothion. Effect of alkyl chain length, nucleophile concentration and pH on the rate of reaction of fenitrothion has also been studied.

Keywords: Fenitrothion, Cationic surfactant, Hydrolysis, α-Nucleophiles

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2010
Page: [194 - 199]
Pages: 6
DOI: 10.2174/157018010790596650
Price: $58