Synthesis of N-Succinyl-L,L-Diaminopimelic Acid Mimetics Via Selective Protection

Author(s): V. Vanek, J. Picha, M. Budesinsky, M. Sanda, J. Jiracek, R. C. Holz, J. Hlavacek.

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 3 , 2010

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Abstract:

The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,Ldiaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing the different carboxyl groups or lipophilic moieties on their amino group.

Keywords: Bacterial enzyme, N-succinyl-L, L-diaminopimelic acid (SDAP), synthesis of SDAP analogues, selective protection

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Article Details

VOLUME: 17
ISSUE: 3
Year: 2010
Page: [405 - 409]
Pages: 5
DOI: 10.2174/092986610790780387
Price: $65

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