Immunization with Peptide-Protein Conjugates: Impact on Benchmarking B-Cell Epitope Prediction for Vaccine Design

Author(s): Salvador Eugenio C. Caoili.

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 3 , 2010

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Benchmarking B-cell epitope prediction for vaccine design is meaningful if based on empirical reference data pertaining to cross-reactivities of antipeptide antibodies with native protein antigens; yet it is complicated by such data acquired using antibodies raised against peptide-protein conjugates, as peptide-protein conjugation can differentially suppress antibody responses to peptide epitopes.

Keywords: B-cell epitope prediction, peptide-based vaccine, antipeptide antibody, peptide-protein cross-reactivity, peptideprotein conjugation, structural energetics

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Article Details

Year: 2010
Page: [386 - 398]
Pages: 13
DOI: 10.2174/092986610790780288
Price: $65

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