Bryothamnion seaforthii Lectin Relaxes Vascular Smooth Muscle: Involvement of Endothelium and NO Synthase

Author(s): Ricardo F. Lima, David N. Criddle, Pedro Marcos G. Soares, Samile Pereira Ribeiro, Benildo S. Cavada, Kyria S. Nascimento, Alexandre H. Sampaio, Ana Maria S. Assreuy.

Journal Name: Protein & Peptide Letters

Volume 17 , Issue 3 , 2010

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Abstract:

Bryothamnion seaforthii lectin (BSL) induced reversible concentration-related relaxation of endothelized aorta, maximal at 30μg/ml (IC50= 4.8 ± 0.6μg/ml). This effect was inhibited by L-NAME and reversed by mucin, probably via interaction with a specific lectin-binding site on the endothelium activating nitric oxide synthase.

Keywords: Lectin, agglutinin, Bryothamnion seaforthii, nitric oxide synthase, red marine alga

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Article Details

VOLUME: 17
ISSUE: 3
Year: 2010
Page: [305 - 310]
Pages: 6
DOI: 10.2174/092986610790780332
Price: $65

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