Mechanisms of the Resistance and Tolerance to Beta-Lactam and Glycopeptide Antibiotics in Pathogenic Gram-Positive Cocci

Author(s): A. Mlynarczyk , B. Mlynarczyk , M. Kmera-Muszynska , S. Majewski , G. Mlynarczyk .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 13 , 2009

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Abstract:

Beta-lactams are the most frequently used antimicrobials in combating infections. In the case of gram-positive bacteria resistant to beta-lactams, glycopeptides are the first choice. The occurrence, mechanisms and genetic background of the resistance of pathogenic staphylococci, streptococci and enterococci to beta-lactam and glycopeptide antibiotics were discussed. The resistances to well-established antimicrobials, as well as new agents (ceftobiprole, oritavancin, telavancin, dalbavancin) were taken into consideration in the text.

Keywords: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Enterococcus faecalis, Enterococcus faecium, antibiotic resistance, SCCmec, plasmids, transposons

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Article Details

VOLUME: 9
ISSUE: 13
Year: 2009
Page: [1527 - 1537]
Pages: 11
DOI: 10.2174/138955709790361557
Price: $58

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