Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Hologram QSAR Studies of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides Derivatives as Selective Peripheral Benzodiazepine Receptor Ligands

Author(s): M. Ye.

Abstract:

Peripheral benzodiazepine receptor (PBR) is an important target for the development of drugs to treat anxiety and sleep disorders. Hologram QSAR models were built for good statistical results. Contribution map analysis explains the individual atomic contributions to the overall activity. This HQSAR model should be useful for the further development of novel structurally related PBR ligands.

Keywords: Peripheral benzodiazepine receptor, Hologram QSAR

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2010
Page: [133 - 138]
Pages: 6
DOI: 10.2174/157018010790225886
Price: $58