Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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3D-QSAR Study on Ring Substituted Imidazoles for Their Antitubercular Activity

Author(s): Gyanendra Kumar Sharma, Devender Pathak.

Abstract:

Ring substituted imidazoles are the emerging class of antitubercular agents. CoMFA model for various ring substituted imidazoles is used to elucidate their structure activity relationships. Both the training set and test set compounds were modeled to the established procedures and were aligned. There was a good correlation between the predicted and experimental activities for both the test set and training set compounds by CoMFA model. Structure activity relations have been established based on the obtained contour maps from the 3D-QSAR analysis.

Keywords: Ring substituted imidazoles, Antitubercular activity, CoMFA, 3D-QSAR

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2010
Page: [128 - 132]
Pages: 5
DOI: 10.2174/157018010790225912
Price: $58