Studies on the Pharmacokinetics of Methotrexate by Scintigraphic Monitoring of [99mTc]Pteridinic Derivatives Biodistribution
R. G. Fumarel,
M. L. Pascu.
Methotrexate (MTX) use associated with optical irradiation of the malignant tumours requires knowledge of its intratumoral retention time. Radioactive Chromatography and absorption spectroscopy confirm synthesizing of 2,4 diamino 6-pertechnetate pterine that pursues MTX biodistribution. Sequential scintigraphy shows an intratumoral MTX retention time of one hour from systemic administration in bolus.
Keywords: Methotrexate, Photosensitiser, Radioactive labelling, Radioactive chromatography, Gel filtration, Scintigraphy
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