Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Studies on the Pharmacokinetics of Methotrexate by Scintigraphic Monitoring of [99mTc]Pteridinic Derivatives Biodistribution

Author(s): R. G. Fumarel, P. Alber, A. Hurduc, N. Stafidov, M. L. Pascu.

Abstract:

Methotrexate (MTX) use associated with optical irradiation of the malignant tumours requires knowledge of its intratumoral retention time. Radioactive Chromatography and absorption spectroscopy confirm synthesizing of 2,4 diamino 6-pertechnetate pterine that pursues MTX biodistribution. Sequential scintigraphy shows an intratumoral MTX retention time of one hour from systemic administration in bolus.

Keywords: Methotrexate, Photosensitiser, Radioactive labelling, Radioactive chromatography, Gel filtration, Scintigraphy

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2010
Page: [98 - 101]
Pages: 4
DOI: 10.2174/157018010790225859
Price: $58