Current Rheumatology Reviews

Dr. Serena Guiducci  
Department of Biomedicine, Division of Rheumatology
University of Florence
Florence
Italy

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A Potential Role of Diet in Modulating Peroxisome Proliferator-Activated Receptor (PPAR)-Mediated Signalling in Arthritis

Author(s): Minako Murata, Kayo Masuko.

Abstract:

Members of the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors are key regulators of glucose and lipid metabolism. Recent studies have demonstrated that PPAR activation plays an important role in inflammatory arthritis. A variety of natural ligands including nutritional elements are known to activate PPARs, suggesting the contribution of dietary nutrients to the regulation of PPAR-mediated gene transcription in the nucleus. This mini-review introduces some aspects of the potential role of these nutrients in modulating the pathophysiology of arthritis through PPAR signalling.

Keywords: PPARs, diet, nutrient, arthritis, review

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Article Details

VOLUME: 5
ISSUE: 4
Year: 2009
Page: [246 - 251]
Pages: 6
DOI: 10.2174/157339709790192521
Price: $58