Current Respiratory Medicine Reviews

Joseph Varon  
The University of Texas Health Science Center
Houston, TX
USA

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Association Between Chlamydia pneumoniae Antibodies and Lung Cancer: A Meta-Analysis

Author(s): Zhuang Liu, Zhi-hua Yin, Hui-ying Liang, Zhi-fang Jia, Bao-sen Zhou.

Abstract:

To evaluate the relationship between Chlamydia pneumoniae infection and lung cancer, we conducted a metaanalysis of studies comparing the antibodies of C. pneumoniae between lung cancer patients and controls. The random-effects model or fixed-effects model was used according to the results of heterogeneity tests. Total, 8 studies with 1602 cases and 1734 controls were included. The analysis showed that the pooled OR of the association between C. pneumoniae IgA and lung cancer was 1.82 (95% CI, 1.21-2.74), while the association between C. pneumoniae IgG and lung cancer was 1.77 (95% CI, 1.13-2.78). Thus, statistically significant differences were observed between C. pneumoniae antibodies and lung cancer. This meta-analysis suggests that C. pneumoniae infection may be a potential risk factor for lung cancer.

Keywords: Chlamydia pneumoniae, lung cancer, meta-analysis

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Article Details

VOLUME: 6
ISSUE: 3
Year: 2010
Page: [201 - 206]
Pages: 6
DOI: 10.2174/157339810791526111
Price: $58