Novel Derivatives of 1,3-Dimethyl-5-methylenebarbituric Acid
Kamal Sweidan, Qutaiba Abu-Salem, Ahmed Al-Sheikh and Ghassan Abu Sheikha
Affiliation: Faculty of Pharmacy, Al-Zaytoonah University, P.O. Box 130 Amman, Jordan.
The ability of the pyridinium adduct of 1,3-dimethyl-5-methylenebarbituric acid (2) to undergo nucleophilic substitution reaction has been examined. Various types of nucleophiles, including cyanide, barbiturate, sulfide anions and 1,2-bis(diphenylphosphino)ethane substitute the pyridinium fragment in 2 leading to synthesis of new organic derivatives.
Keywords: 1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (1,3-dimethylbarbituric acid), zwitterionic pyridinium adduct, nucleophilic substitution reaction
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