Labeling of Oligopeptides with Luminescent Lanthanide(III) Chelates on Solid Phase

Author(s): Jari Peuralahti, Lassi Jaakkola, Harri Hakala, Veli-Matti Mukkala, Jari Hovinen.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 8 , 2009

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Abstract:

Synthesis of a building block based on 6,6-(1H-pyrazole-1,3-diyl)bis(pyridine) (3) that allows introduction of photoluminescent lanthanide(III) chelates to the synthetic oligopeptides on solid phase using the standard Fmoc chemistry is described. Since the ligand based on (3) forms luminescent chelates with Eu3+, Sm3+, Tb3+ and Dy3+ ions, the ligand is highly useful for multiparametric homogenous assays simplifying considerably the preparation of chelates needed in these applications.

Keywords: Lanthanide(III) chelates, oligopeptides, solid phase synthesis, labeling

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Article Details

VOLUME: 6
ISSUE: 8
Year: 2009
Page: [659 - 663]
Pages: 5
DOI: 10.2174/157017809790442998
Price: $58

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