Abstract
An easy solid phase synthesis of oxytocin analogues conjugated to polyaminopolycarboxylic ligand, such as diethylenetriaminepentaacetic acid (DTPA) and tetraazacyclododecanetetraacetic acid (DOTA) is reported. These new products can be labeled with suitable radiometals (e.g. 90Y, 111In, 177Lu), giving rise to radiopharmaceuticals with potential application in imaging and/or therapy of tumors over-expressing oxytocin receptors.
Keywords: Oxytocin, solid phase peptide synthesis, targeting, DOTA, DTPA, radiolabeled peptides
Letters in Organic Chemistry
Title: Solid Phase Synthesis of Oxytocin Analogues Conjugated to Polyamino Polycarboxylic Ligands
Volume: 6 Issue: 8
Author(s): Luciano Lattuada, Enrico Cappelletti, Mario De Miranda and Chiara Umbelli
Affiliation:
Keywords: Oxytocin, solid phase peptide synthesis, targeting, DOTA, DTPA, radiolabeled peptides
Abstract: An easy solid phase synthesis of oxytocin analogues conjugated to polyaminopolycarboxylic ligand, such as diethylenetriaminepentaacetic acid (DTPA) and tetraazacyclododecanetetraacetic acid (DOTA) is reported. These new products can be labeled with suitable radiometals (e.g. 90Y, 111In, 177Lu), giving rise to radiopharmaceuticals with potential application in imaging and/or therapy of tumors over-expressing oxytocin receptors.
Export Options
About this article
Cite this article as:
Lattuada Luciano, Cappelletti Enrico, De Miranda Mario and Umbelli Chiara, Solid Phase Synthesis of Oxytocin Analogues Conjugated to Polyamino Polycarboxylic Ligands, Letters in Organic Chemistry 2009; 6 (8) . https://dx.doi.org/10.2174/157017809790443023
DOI https://dx.doi.org/10.2174/157017809790443023 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Targeting Epigenetics in Nervous System Disease
CNS & Neurological Disorders - Drug Targets Resveratrol and Cancer Treatment: Is Hormesis a Yet Unsolved Matter?
Current Pharmaceutical Design Modulation of the Cannabinoid System: A New Perspective for the Treatment of the Alzheimer’s Disease
Current Neuropharmacology Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?
CNS & Neurological Disorders - Drug Targets Cannabinoid System as a Potential Target for Drug Development in the Treatment of Cardiovascular Disease
Current Vascular Pharmacology Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?
Current Neuropharmacology Lipoxygenase Inhibitors as Cancer Chemopreventives: Discovery, Recent Developments and Future Perspectives
Current Medicinal Chemistry Heat Shock Proteins And Neuroprotection
Recent Patents on DNA & Gene Sequences Methionine Aminopeptidases as Potential Targets for Treatment of Gastrointestinal Cancers and other Tumors
Current Drug Targets T Cell Costimulatory and Inhibitory Receptors as Therapeutic Targets for Inducing Anti-Tumor Immunity
Current Cancer Drug Targets Editorial [Hot topic: Sigma1 and Sigma 2 Receptors (Guest Editor: Richard A. Glennon)]
Central Nervous System Agents in Medicinal Chemistry Nitric Oxide Synthases and Their Natural Inhibitors
Current Enzyme Inhibition Promotion of Apoptosis in Cancer Cells by Selective Purine-Derived Pharmacological CDK Inhibitors: One Outcome, Many Mechanisms
Current Pharmaceutical Design Scientific Basis for the Use of Indian Ayurvedic Medicinal Plants in the Treatment of Neurodegenerative Disorders: 1. Ashwagandha
Central Nervous System Agents in Medicinal Chemistry Voltage-Gated Sodium Channels in Neurological Disorders
CNS & Neurological Disorders - Drug Targets NAD Biosynthesis in Humans - Enzymes, Metabolites and Therapeutic Aspects
Current Topics in Medicinal Chemistry Psychotropic Medications and the Treatment of Human Prion Diseases
CNS & Neurological Disorders - Drug Targets Murine Models of Vpr-Mediated Pathogenesis
Current HIV Research Proteasome Inhibitors in Cancer Therapy
Current Drug Targets Microglia-Neuron Interaction in Inflammatory and Degenerative Diseases: Role of Cholinergic and Noradrenergic Systems
CNS & Neurological Disorders - Drug Targets