Solid Phase Synthesis of Oxytocin Analogues Conjugated to Polyamino Polycarboxylic Ligands

Author(s): Luciano Lattuada, Enrico Cappelletti, Mario De Miranda, Chiara Umbelli.

Journal Name: Letters in Organic Chemistry

Volume 6 , Issue 8 , 2009

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Abstract:

An easy solid phase synthesis of oxytocin analogues conjugated to polyaminopolycarboxylic ligand, such as diethylenetriaminepentaacetic acid (DTPA) and tetraazacyclododecanetetraacetic acid (DOTA) is reported. These new products can be labeled with suitable radiometals (e.g. 90Y, 111In, 177Lu), giving rise to radiopharmaceuticals with potential application in imaging and/or therapy of tumors over-expressing oxytocin receptors.

Keywords: Oxytocin, solid phase peptide synthesis, targeting, DOTA, DTPA, radiolabeled peptides

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Article Details

VOLUME: 6
ISSUE: 8
Year: 2009
Page: [624 - 629]
Pages: 6
DOI: 10.2174/157017809790443023
Price: $58

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