Abstract
The cannabinoid CB2 receptor continues to be an intriguing target for the potential therapeutic benefit of cannabinoids. Because this receptor is significantly found outside the brain, compounds specific for the CB2 receptor may be free of the side effects that have plagued cannabinoid CB1 receptor-based therapeutics. In this review, we will discuss a class of compounds which modulate the constitutive activity of the cannabinoid CB2 receptor, the inverse agonists. We will discuss recent chemical advances that provide new compounds to investigate the biology based on this pharmacology. We will then discuss new biology associated with the cannabinoid CB2 receptor for hints of how these compounds can best be utilized in vivo.
Keywords: Cannabinoid CB2 receptor, inverse agonist, constitutive activity, inflammation, migration, cannabidiol
Current Topics in Medicinal Chemistry
Title: Updating the Chemistry and Biology of Cannabinoid CB2 Receptor – Specific Inverse Agonists
Volume: 10 Issue: 8
Author(s): Charles A. Lunn
Affiliation:
Keywords: Cannabinoid CB2 receptor, inverse agonist, constitutive activity, inflammation, migration, cannabidiol
Abstract: The cannabinoid CB2 receptor continues to be an intriguing target for the potential therapeutic benefit of cannabinoids. Because this receptor is significantly found outside the brain, compounds specific for the CB2 receptor may be free of the side effects that have plagued cannabinoid CB1 receptor-based therapeutics. In this review, we will discuss a class of compounds which modulate the constitutive activity of the cannabinoid CB2 receptor, the inverse agonists. We will discuss recent chemical advances that provide new compounds to investigate the biology based on this pharmacology. We will then discuss new biology associated with the cannabinoid CB2 receptor for hints of how these compounds can best be utilized in vivo.
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Cite this article as:
A. Lunn Charles, Updating the Chemistry and Biology of Cannabinoid CB2 Receptor – Specific Inverse Agonists, Current Topics in Medicinal Chemistry 2010; 10 (8) . https://dx.doi.org/10.2174/156802610791164193
DOI https://dx.doi.org/10.2174/156802610791164193 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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