α-N-Heterocyclic Thiosemicarbazone Derivatives as Potential Antitumor Agents: A Structure-Activity Relationships Approach

Author(s): Ana I. Matesanz, Pilar Souza.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 12 , 2009

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Abstract:

α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships.

Keywords: α-N-heterocyclic thiosemicarbazone, bis(thiosemicarbazone), ribonucleotide reductase inhibitors, antitumour agents, metal complexes, structure-activity relationships

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Article Details

VOLUME: 9
ISSUE: 12
Year: 2009
Page: [1389 - 1396]
Pages: 8
DOI: 10.2174/138955709789957422
Price: $58

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