Ligands of Diltiazem Binding Site: An Overview of Some Chemotypes

Author(s): R. Budriesi , P. Ioan , E. Carosati , G. Cruciani , B. S. Zhorov , A. Chiarini .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 9 , Issue 12 , 2009

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Abstract:

The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.

Keywords: (+)-cis-Diltiazem, L-type calcium channels, benzothiazepine, chemotype, computational approaches, voltage gated calcium channel, calcium entry blockers, structural and functional analogs

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Article Details

VOLUME: 9
ISSUE: 12
Year: 2009
Page: [1379 - 1388]
Pages: 10
DOI: 10.2174/138955709789957369
Price: $58

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